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Very low calorie diets (below 800 calories daily) should only be done under direct medical supervision with appropriate supplementation and monitoring
To overcome this limitation, synthetic GLP-1 analogues like semaglutide, Wegovy, Ozempic, Rybelsus, Retatrutide, and Tirzepatide have been developed
Following a "low and slow" approach starting with a small dose and gradually increasing it allows the digestive system to adapt and significantly reduces discomfort
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