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It seems to me that while GLP-1 medications may be shrinking waistlines, Big Food is working hard to ensure its bottom line doesnt follow suit
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For eGFR below 45, canagliflozin should be discontinued for glycemic indications, though it may be continued for its cardio-renal indications down to eGFR 30 [2]
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2.3 GLP-1RA modulation of promotion cholesterol efflux Beyond inflammation, impaired cholesterol efflux from macrophage-derived foam cells, mediated by key transporters such as ABCA1 and ABCG1, contributes to intracellular lipid accumulation and promotes plaque progression and instability ( A study in 2022 demonstrated that targeted GLP-1RA nanoparticles directly reduced vascular inflammation in ApoE/ mice, even at doses too low to affect glycemia or body weight ( Tnf and Icam1 expression with a concomitant increase in Arg1 , a marker of alternative macrophage activation
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