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Reddit users often post about experiencing a weight loss plateau while taking a GLP-1 medication, even after an initial period of steady progress

Pros and Cons: Pros: Can make the skin tone lighter and more even

For example, a patient who does not have insurance coverage may be better suited for phentermine, which is relatively inexpensive

Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years

Athletes & gym-goers aiming to burn fat & enhance endurance