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Other signal transduction systems and metabolic pathways involved in the MGB-based cause of depression include the endocannabinoid system, CAMKII-CREB and MAPK signaling, and glycerophospholipid metabolism

doi:10.1038/s41586-020-2025-2

Over the past five or 10 years, methylene blue has come to be touted online as a so-called nootropic agent a substance that enhances cognitive function

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It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)