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Markers of hemolysis follow a predictable pattern: Unconjugated (indirect) bilirubin: elevated released from destroyed cells Lactate dehydrogenase (LDH): elevated a general cell-damage marker Haptoglobin: low consumed as it binds free hemoglobin Urinalysis: hemoglobinuria during severe intravascular hemolysis G6PD Enzyme Activity Tests These directly measure how much enzyme is working in the red cells

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With improved synthetic/natural polymer designs along with an improved ability to innocuously adapt to tissues and organs, biomaterial-based biomedical applications have expanded tremendously