compounding glp-1 of Drugs | STOP Obesity Alliance | Milken Institute School of Public Health What to Expect When Switching

Requires medical supervision for proper dosing and side effect management

Physiol Rev (2015) 95(2):51348

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For example, medications like liraglutide and semaglutide have been shown to lower the risk of major cardiovascular events in people with diabetes, independent of their effects on blood sugar

Specifically, the decrease in SIRT1 levels, inhibition of its activity, or generation of mutations that lower its activity have been linked to intestinal inflammation and colitis in human and rodent models (Wellman et al., 2017)